Some programs have issues when running on kernels with larger pagesizes.
jemalloc
One common case is programs (especially rust programs) that use jemalloc. this was fixed in #48194 for the jemalloc package itself and all rust packages built in the future, but some packages still may need a rebuild. This often manifests itself like this:
<jemalloc>: Unsupported system page size
<jemalloc>: Unsupported system page size
memory allocation of 5 bytes failed
Probably broken
as yet untested, based on https://github.com/AsahiLinux/docs/wiki/Broken-Software#broken-packages
broken