A complete, high-yield MCAT study system built on clinical reasoning, ICU physiology, and medical pattern recognition.

This repository contains a full set of clinically oriented MCAT study notes, organized by discipline and optimized for rapid retention, pattern recognition, and application under exam pressure.

Unlike traditional MCAT materials, this system reframes foundational science in the language of:

• physiology
• pharmacology
• critical care medicine
• molecular mechanisms
• clinical diagnostics
• real-world reasoning

This allows complex material to be learned faster, retained longer, and applied more accurately, especially for those with medically oriented cognition.

Most MCAT resources rely on memorization.
This framework relies on pattern-based, clinical interpretation, mirroring how physicians think:

• cause → mechanism → effect
• metabolic shifts → clinical states
• enzyme kinetics → drug behavior
• signaling pathways → hormones you actually manage
• protein folding → cellular stress
• biochemistry → ICU physiology

If a concept has no clinical anchor, you are far less likely to retain it.
Here, every major topic is tied to how it appears in real physiology.

MCAT/
│
├── biochemistry/
│   ├── README.md                     # Clinical Biochemistry Guide
│   └── notes/                        # Subsections (AA, enzymes, metabolism...)
│
├── biology/
│   └── README.md                     # Cellular physiology + clinically relevant mechanisms
│
├── chemistry-physics/
│   └── README.md                     # OR physics, fluids, gas laws, imaging, kinetics
│
├── psychology-sociology/
│   └── README.md                     # Behavioral science translated into real clinical scenarios
│
├── cars/
│   └── README.md                     # Pattern-based CARS reasoning framework
│
└── practice/
    └── question-breakdowns.md        # MCAT → ICU/OR scenario conversions

Each section is self-contained but built on the same clinical logic.

All science concepts are linked to:

• shock states
• anesthesia pharmacology
• mitochondrial dysfunction
• endocrine crises
• membrane physiology
• metabolic stress

This turns abstract facts into meaningful mechanisms.

Rather than teaching 10,000 facts, this system teaches 200 reusable patterns that answer 80–90% of MCAT questions.

Only the clinically necessary information is included.
No clutter. No noise. No irrelevant trivia.

If you think better with:

• physiology
• clinical reasoning
• drug mechanisms
• patient scenarios

...this system amplifies that strength.

• Premed students with clinical backgrounds
• Nontraditional applicants
• Students who struggle with pure memorization
• Learners who want a mechanism-first understanding
• Anyone wanting to score higher by thinking like a future clinician

1. Begin with biochemistry — the foundation of MCAT reasoning.
2. Move to biology and physiology, which follow the same clinical logic.
3. Then cover chem/phys using OR/ICU physical principles.
4. Use psych/soc as clinical behavior patterns.
5. Apply everything with practice-to-clinic conversions.

This is an evolving clinical MCAT framework.
Content updates, clarifications, and expansions are welcome.

This project is licensed under the terms specified in the root LICENSE file.

This is the MCAT as it should be studied:
not as disconnected facts, but as living physiology.

If you understand the patterns,
you understand the exam.
If you understand the mechanisms,
you never forget them.

This framework was iteratively refined using paid third-party MCAT practice resources (eg, UWorld) to identify high-yield reasoning patterns and common conceptual traps. No proprietary content is reproduced.

If you use or adapt this material, please cite:

George, C. B. (2025). MCAT Clinical Mastery Notes.
https://github.com/collingeorge/MCAT-Clinical-Mastery