This app prototype for displaying bNABs epitope data by participant
The following layout was used as a template for displaying data.
Data follows the structure below:
| Epitope | Env location | Residues (amino acids/ regions) | References | epitopeID |
|---|---|---|---|---|
| CD4-binding site | 276-282 | Loop D; key contacts - PNGS (N*S/T) N279-280 | West et al, PNAS, 2012 | Loop D |
| CD4-binding site | 365-371 | CD4-binding site (bs) loop; key contact - D368 | West et al, PNAS, 2012 | bs loop |
| CD4-binding site | 456-469 | V5 loop; key contact – R456 | West et al, PNAS, 2012 | V5 loop |
| V2-apex | 166 | Arginine (R) | Andrabi et al., Immunity, 2015 | V2-apex |
| V2-apex | 168-171 | Lysine (K)-rich | Haynes et al., Nat Immunol Rev., 2022 | V2-apex |
| V2-apex | 156, 160 | PNGS (N*S/T) | Haynes et al., Nat Immunol Rev., 2022 | V2-apex |
| V3-glycan | 301, 332 | PNGS (N*S/T) | Haynes et al., Nat Immunol Rev., 2022 | V3-glycan |
| V3-glycan | 324-327 | GDIR | Haynes et al., Nat Immunol Rev., 2022 | V3-glycan |
| Gp41 MPER | 662-667 | ELDKWA | Munir, Haynes, et al. (Duke) | Gp41-1 |
| Gp41 MPER | 671-676 | NWFNIT | Munir, Haynes, et al. (Duke) | Gp41-1 |
| Gp41 fusion peptide | 512-527 | AVGIGAVFLGFLGAAG | Kong et al., Science, 2016 | Gp41-2 |
| Gp120-gp41 interface | 611 (gp41) | PNGS (N*S/T) | Falskowka et al., Immunity, 2014 | Interface-1 |
| Gp120-gp41 interface | 637 (gp41) | PNGS (N*S/T) | Falskowka et al., Immunity, 2014 | Interface-2 |
| Gp120-gp41 interface | 276 (gp120) | PNGS (N*S/T) | Falskowka et al., Immunity, 2014 | Loop D |
| Gp120-gp41 interface | 448 (gp120) | PNGS (N*S/T) | Falskowka et al., Immunity, 2014 | Interface-3 |
NB: (1) PNGS – potential N-linked glycosylation site; (2) residues are listed as amino acids
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Ensure your Docker client is running
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Run the following commands in this directory:
docker-compose v.1.xx
docker-compose builddocker-compose updocker-compose v.2.xx
docker compose builddocker compose up
Note: This does not show changes made to the code without a rebuild.
- Open a webpage at localhost:3000
Run the following command in this directory:
docker-compose v.1.xx
docker-compose down
docker-compose v.2.xx
docker compose down