Implement empirical p-value formula by comparing with non-targeting distribution

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garrett:

(re: multiple testing correction for Abe, I think you should just kind of forget it. The goal would be FDR control, and I don't think any procedure can do better than the empirical FDR provided by the negative control distribution.)

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https://www.cell.com/ajhg/fulltext/S0002-9297(07)60491-1