diff --git a/CHANGELOG.md b/CHANGELOG.md
index 238fea9..413cb6a 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -1,5 +1,12 @@
 # Changelog
 
+## [0.4.3](https://github.com/googleapis/python-datastream/compare/v0.4.2...v0.4.3) (2022-06-07)
+
+
+### Bug Fixes
+
+* **deps:** require protobuf<4.0.0 on v0 branch ([#106](https://github.com/googleapis/python-datastream/issues/106)) ([5d6bf4a](https://github.com/googleapis/python-datastream/commit/5d6bf4aa15a813564599eb6c6674d8019bcae289))
+
 ### [0.4.2](https://github.com/googleapis/python-datastream/compare/v0.4.1...v0.4.2) (2022-03-05)
 
 
diff --git a/setup.py b/setup.py
index 30a9129..12a87ed 100644
--- a/setup.py
+++ b/setup.py
@@ -22,7 +22,7 @@
 
 name = "google-cloud-datastream"
 description = "Datastream client library"
-version = "0.4.2"
+version = "0.4.3"
 release_status = "Development Status :: 3 - Alpha"
 url = "https://github.com/googleapis/python-datastream"
 dependencies = [
@@ -30,7 +30,8 @@
     # Until this issue is closed
     # https://github.com/googleapis/google-cloud-python/issues/10566
     "google-api-core[grpc] >= 1.31.5, <3.0.0dev,!=2.0.*,!=2.1.*,!=2.2.*,!=2.3.0",
-    "proto-plus >= 1.15.0",
+    "proto-plus >= 1.15.0, <2.0.0dev",
+    "protobuf<4.0.0dev",
 ]
 
 package_root = os.path.abspath(os.path.dirname(__file__))