Drug Concentration Modelling in the Human
Bloodstream
By,
Hasibur Rahaman
Submitted to,
Assistant Professor Dr. Rajesh Mondal
(Department of Mathematics , Bejoy Narayan Mahavidyalaya)
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DEDICATION
I dedicate this work on the Drug Concentration Modelling in the
Human Bloodstream to all the curious minds, both past and present,
who have been captivated by the allure of this beautiful topic.
Joseph Fourier, Pierre-Simon Laplace, Michele Caputo, Bernhard
Riemann and modern researchers such as Muath Awadalla who
contributed greatly to this field of mathematics, I dedicate this work as
a tribute to your ingenuity and the legacy you left behind.
To my mentors and teachers, who have patiently guided and
inspired me along this journey, I dedicate this work to express my
gratitude for your unwavering support, invaluable guidance and
profound wisdom. Your passion for Mathematics has ignited a flame
within me that will continue to burn brightly.
Finally, I dedicate this work to the beauty of Mathematics itself. May
this beautiful topic of Mathematics continue to fascinate and
inspiration generations to come.
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DECLARATION
I hereby declare that this project has been submitted for the paper
DSE-4 for the fulfilment of Mathematics (Hons.) degree under The
University of Burdwan. No part or whole of this project has been
submitted elsewhere for any other degree or diploma.
__________________________
Signature of the Student
Date:- .
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CERTIFICATE
This is to certify that the project titled ‘Drug Concentration
Modelling in the Human Bloodstream’ submitted by Hasibur
Rahaman is an original work conducted under my guidance.
This project is a culmination of Hasibur Rahaman’s
independent research and reflects his own efforts, ideas and
analysis. It has been undertaken as a requirement for the course
titled ‘BMH6PW01’ at Bejoy Narayan Mahavidyalaya.
I commend Hasibur Rahaman for his dedication, commitment
and diligent efforts throughout the completion of this project.
_________________________
Signature of the Teacher
Date:- .
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ACKNOWLEDGEMENT
I would like to express my sincere gratitude and appreciation to all
those who have contributed to the development and understanding of
Drug Concentration Modelling in the Human Bloodstream. Without
their dedication, insights, and efforts, this research would not have
been possible.
First and foremost, I would like to extend my deepest thanks to all
the brilliant mathematicians who contributed greatly to this field. Their
pioneering work laid the foundation for the exploration and study of
this fascinating mathematical phenomenon.
I am immensely grateful to my professor Dr. Rajesh Mondal for his
invaluable guidance and encouragement throughout this project. His
expertise in mathematical biology and dedication as a mentor have
greatly enriched this work and played a pivotal role in shaping my
understanding of discrete population models.
I would like to extend my gratitude to my friends and family for
their unwavering support and encouragement throughout this
endeavour. Their belief in my abilities and their constant motivation
have been instrumental in overcoming challenges and pursuing this
research with enthusiasm.
To everyone mentioned above and to those whose names may have
been inadvertently omitted, please accept my heartfelt appreciation
for your contributions to the field of Mathematics.
________________________
Signature of the Student
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Index :-
1. Abstract
2. Introduction
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1. Abstract :-
This project focuses on the mathematical modelling of drug
concentration in the human bloodstream, a vital component of
pharmacokinetics that ensures safe and effective therapeutic
outcomes. Traditional models typically employ classical first-order
differential equations to describe the exponential decay of drug levels
over time. However, these models often oversimplify the complex
physiological processes involved, particularly the memory and
hereditary effects inherent in drug absorption, distribution,
metabolism, and excretion.
To address these limitations, this study introduces advanced
modelling techniques using fractional calculus, specifically the Caputo,
Caputo-Fabrizio, and Psi-Caputo fractional derivatives. These fractional
models offer greater flexibility and accuracy by incorporating non-
integer orders of differentiation, which better capture the real
dynamics of drug behaviour in the body. Theoretical analyses,
including proofs of existence and uniqueness of solutions and stability
studies using Ulam-Hyers criteria, validate the robustness of these
models.
Numerical simulations further illustrate the advantages of fractional
models, demonstrating more realistic predictions of drug concentration
over time compared to classical models. The results highlight the
potential of fractional pharmacokinetic models to improve dosage
design, minimize toxicity, and support personalized medicine
approaches.
Overall, this project showcases the power of mathematical
modelling, especially fractional differential equations, as essential tools
in biomathematics to enhance drug therapy strategies and patient
care.
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2. Introduction :-
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