Human Longevity and Aging

What if your brain and immune system are the real keys to longevity? 🔥 Just out in Nature Medicine 🔥 “Plasma proteomics links brain and immune system aging with healthspan and longevity” by Hamilton Se-Hwee Oh, Tony Wyss-Coray, Anne Brunet, Michael Greicius & colleagues We often talk about aging as a slow, systemic decline ; but what if the real story is about a few crucial organs pulling the strings? We've been studying how immune system aging drives systemic decline for almost 2 decades and reading this elegant paper reaffirms this claim. In this massive study of ~45,000 people from the UK Biobank, Tony's group built machine learning models that estimate the biological age of 11 organs from plasma proteins. 🧬 Key insights: ✅ Each organ ages independently —> brain and immune system stand out ✅ Aged brains increase Alzheimer’s risk as much as carrying an APOE4 allele ✅ Aged immune systems drive mortality and chronic diseases ✅ Youthful brains and immune systems reduce mortality risk by nearly 60% ✅ Individuals with both youthful organs had the lowest death risk of all (HR = 0.44) ✅ Plasma proteomics tracks aging better than existing clinical clocks (like PhenoAge) 💡 The promise for longevity: If we can measure, protect, and intervene on the aging of specific organs — especially the brain and immune system — we might delay chronic disease and extend healthspan. Massive kudos to the phenomenal team across Stanford, the UK Biobank Pharma Proteomics Project, and the Wu Tsai Neurosciences Institute for making this possible. A milestone in translational aging science! BRAIN AND IMMUNE SYSTEM YOUTH PREDICT LONGEVITY #longevity #aging #biomarkers #proteomics #brainhealth #immunology

A secret weapon to creating longevity of life is to exercise your mind. We all have known about working your body. But it's equally important to be relentless about working your mind. The hard truth is that this is a hard habit to develop for most people by the time they realize they need to do so. For those of you who are young enough to aggressively develop this habit, please... START! 1. Read (books, not just captions) 2. Explore subject matters laterally and vertically 3. Create and build Si Ramo, who was my mentor and founder of TRW (now Northrop Grumman), lived until he was 103. In his early 80s, Si was an active mentor to me when I as NASA Administrator. He kept up with the latest space business news and provided very focused suggestions. He also engaged the media where he could be helpful. In his 90s, he and I met for lunch once a quarter and enjoyed engaging in conversations about music, technology, politics and the state of our nation. We'd also go out on double dates with our wives and the four of us would always be the last ones left in the restaurant. Si Ramo also received a patent at 100. I have another (best) friend Bob who is my age. In his 70s, he got his photography collection of translucent composites into the Smithsonian. In his 80s, he completed a masters thesis on epidemiology at the University College London. So many people spend thousands to millions to focus on the financial part of retirement planning. But they seem to forget the things that cost nothing and will provide infinite return!

One of the most promising areas of advancement is in the field of longevity. 1. AI in Longevity Research AI technologies can be used to analyze vast amounts of health data, identify biomarkers as they relate to aging, and understand the complex mechanisms behind longevity. By integrating AI with genomics and biotechnology, researchers may be able to predict health trajectories and personalize medical treatments, reducing morbidity. 2. Personalized Medicine One of the most impactful applications of AI in longevity is in the development of personalized medicine. AI algorithms can process individual genetic information, lifestyle data from wearables and other continuous tools, as well environmental factors to tailor preventive and therapeutic solutions specifically designed for each person's unique biological makeup. 3. Global Collaboration AI is not only a tool but a bridge connecting researchers, clinicians, and innovators worldwide. Through global data sharing and collaboration facilitated by AI, the longevity field is experiencing unprecedented growth and innovation. It allows stakeholders to connect and share ideas and insights. As we look to the future, the potential of AI to transform our understanding and approach to aging is boundless. Let's continue to support and invest in these technologies that promise not only to extend life but to enhance the quality of our years. Yes, we have to ask tough questions about their development and use. That will allow us to shape the technologies to our needs. #Longevity #ArtificialIntelligence #HealthTech #Innovation #PersonalizedMedicine #aging

🕒 Aging Post-40s: Why Does It Seem Faster and How Can We Slow It Down? Have you noticed that once we cross the 40-year mark, it can sometimes feel like the aging process accelerates? Why is that? The answer lies in changes in our body's natural processes, lifestyle habits, and emotional well-being, including the health of our gut microbiome. Here are 10 strategies to embrace a more vibrant, youthful life: Eat for Your Gut Microbiome 🦠: The health of our gut plays a vital role in aging. Supplement Wisely 💊: Supplements like NNM and Resveratrol can have anti-aging effects. Stay Active 🏃♂️: Regular exercise keeps your body fit and youthful. Hydrate Well 💧: Drink plenty of water to keep your skin radiant. Work in your Circadian Rhythm ☀️: Spend more time outside and rebalance your internal clock. Manage Stress 😌: Practice mindfulness to reduce chronic Stress. Get Quality Sleep 🛌: Restorative sleep is essential for rejuvenation. Build Strong Relationships ❤️: Foster social connections for emotional well-being. Avoid Smoking and Excessive Alcohol 🚭🍷: Both can lead to premature aging. Find Your Purpose 🎯: Connecting with your life's purpose can infuse you with energy and vitality. As I get closer to my mid-40s, I aim to age with vitality and wellness. I see my body as the temple of my soul, a precious vessel chosen for this journey. My message to you: Strive to be kind to yourself and nourish your body with the best care, recognizing the sacred connection between body and soul. Please share this post to inspire others! Hi! I'm Dr. Rosemarie Rutecki; I'm a Functional Medicine Practitioner. I help professionals feel, look and perform better from the inside out using the latest cutting-edge functional medicine strategies. Ring my 🔔 for more health tips. #functionalmedicine #guthealth #TheRuteckiMethod

#Longevity in 3 Steps (from Eric Topol, MD) Insights distilled from my recent YouTube interview with the world-renowned physician-scientist. 1️⃣ Move With Purpose – Every Day   • 30 min of aerobic activity 5×/week + resistance training 2 – 3×/week is the most powerful way to lower biological age.   • #Exercise consistently outperforms medication for depression and slashes heart-disease and dementia risk. 2️⃣ Eat Real Food, Not “Food-Like” Products   • Base meals on colorful fruits and vegetables, high-quality protein, and healthy fats.   • Cut ultra-processed foods (they make up 60–70 % of the U.S. diet and drive inflammation).   • No supplement, IV drip, or miracle pill beats a plate of whole foods. 3️⃣ Protect Your Deep #Sleep   • Aim for 7–9 hours with a focus on restorative slow-wave sleep that clears brain toxins and cements memory.   • Quick wins: consistent lights-out/awake times, cool-dark bedroom, “digital sunset” 60 min before bed. 💡 Why it matters: Dr. Topol’s data show these habits can extend health-span by 7–10 quality years, even if you start later in life. 🎥 Watch the full interview on YouTube 📄 See the attached PDF on my notes from this talk. Which habit are you doubling down on this week? Let’s build a community of Super Agers. Share your commitment below! 👇 #Longevity #HealthyAging #Healthspan #SuperAgers #PreventiveMedicine #ExerciseIsMedicine #Nutrition #SleepScience #LifestyleMedicine #AgingWell #EricTopol #DrGPT

A worker shortage is now, shared by Professor Bill Stankiewicz. While concerns of automation displacing workers persist, many countries are already having trouble filling manufacturing jobs—and between declining and aging populations, the situation is likely to get worse. For example, the population of the European Union is projected to peak at 453.3 million in 2026, before gradually declining 7.5 percent to 419.5 million by 2100.2 A more immediate concern for manufacturers, however, is the rising number of retirees. In the United States, the retirement of baby boomers (born between 1946 and 1964) represents about 3.5 million people missing from the labor force compared to pre-2020 trends.3 The U.S. manufacturing sector, in particular, is experiencing a substantial labor shortage, exacerbated by a lack of manufacturing education and training.4 The shortage of skilled workers is projected to lead to as many as 2.1 million unfilled manufacturing jobs through 2030, potentially costing the U.S. economy up to $1 trillion. This makes the efficiencies of Industry 4.0 automation more impactful than ever. Automation can potentially fill in the gaps. If predictive maintenance teams are spread thin, which is the best use of their time? Searching for problems or fixing them?  AI, robotics and automation will help. "The United States has one of the most automated car industries in the world: The ratio of robots to factory workers ranks fifth, tied with Japan and Germany and ahead of China," says Takayuki Ito, President of the International Federation of Robotics. "This is a great achievement of modernization. However, in other key areas of manufacturing automation, the US lags behind its competitors.” The majority of industrial robots are imports from overseas, as there are few robot manufacturers producing in the United States. Globally, 70% of installations are produced by four countries: Japan, China, Germany and South Korea. Within this group, Chinese manufacturers are the most dynamic, with production for their huge domestic market more than tripling in five years (2019-2023). This puts them in second place after Japan. China´s success is based on their national robotics strategy. Its manufacturing industry installed a total of about 280,000 units per year between 2021 and 2023, compared to a total of 34,300 installations in the United States in 2024. Best Regards, Professor Bill Stankiewicz , OSHA Trainer, Heavy Lift & Crane Instructor Savannah Technical College Subject Matter Expert International Logistics Member of Câmara Internacional de Logística e Transportes CIT-at The International Transportation Industry Chamber

Stop Wearing Sleep Deprivation as a Badge of Honor That 4 AM email isn't making you successful; it's sabotaging your performance. 38% of U.S. workers report workplace fatigue, and it's costing them their competitive edge. What sleep deprivation is really stealing from you: ↳ Sharp decision-making abilities ↳ Creative problem-solving skills ↳ Emotional regulation under pressure ↳ Long-term health (increased risks of heart disease, diabetes, and certain cancers) The performance hack most professionals don't know: Here's how to optimize your sleep strategy. ✅ Commit to 7-9 hours of sleep opportunity (not just time in bed) ✅ Create a consistent sleep schedule, yes, even on weekends ✅ Implement a "digital sunset" 90 minutes before bed ✅ Cool your bedroom to 65-68°F for optimal sleep phases ✅ Use blackout curtains or an eye mask to eliminate light pollution ✅ Try strategic 10-20 minute power naps if your schedule allows ✅ Track your sleep quality using wearable technology ✅ Correlate your sleep data with your performance metrics ✅ Adjust your daily schedule based on your natural circadian rhythms Choose one strategy and implement it. Your future self and your business results will thank you. What's the biggest challenge preventing you from getting quality sleep? Drop it in the comments, and let's problem-solve together. #sleepoptimization #executivewellness #performancehacking #askdrpat

Stress Management Builds “Resilience Ready” skills Among Health and Human Service Professionals Navigating #emotionallydemandingcircumstances, feeling responsible for the #welfareofothers and #tightschedules is common among Health and Human Service professionals. Effective #stressmanagement is #notaluxury it's a necessity for #fosteringresilience, #preventingburnout, and maintaining #goodhealth. "Resilience is knowing that you are the only one that has the power and the responsibility to pick yourself up." - Mary Holloway Following are 10 things you can do each day to build “Resilience Ready” skills to support #stressmanagement: -Take #MINDFULPAUSES or short mindful breaks throughout the day to reset and refocus your energy. -Incorporate #PHYSICALACTIVITY or regular exercise to boost endorphins and enhance overall well-being. -Fuel your body with #NUTRITIOUSEATING of wholesome foods to support energy levels and mental clarity. -Foster #SOCIALCONNECTION via spending time with people who are important to you for emotional support and a sense of community. -#TIMEOPTIMIZATION - prioritize tasks, delegate when possible, and set realistic goals to manage workload effectively. -Engage in #SELFREFLECTION to identify stress triggers and develop coping strategies. -#CREATIVEEXPRESSION - explore creative outlets to channel emotions and promote self-expression. -#BOUNDARYSETTING - establish clear boundaries between work and personal life to prevent burnout and maintain balance. -Practice deep #BREATHINGTECHNIQUES to calm the mind and reduce stress responses. -Invest in #CONTINOUSLEARNING and skill development to stay resilient and adaptable. Th!nk Possibilities!!! Choose at least one practice to integrate into your #dailyroutine. If you want to pick something not on this list, please share it below. By prioritizing stress management, you build another “Resilience Ready” skill that will empower you to #thrive in #challengingenvironments and continue providing exceptional care and support to others

For our longevity, happiness and to proactively enhance our health, what are some key actions that we can take? In the Emory University School of Medicine CBCT course that I certified as a teacher in, we learned about an evidence based approach that reduced stress levels, reduced inflammatory hormones that can cause disease, and helped focus. This was done by raising awareness of how our mind can influence our ability to think clearly, as well as influence our emotions. There is a great deal of research supporting this. In one study of second year medical students undergoing training, a group was randomized to the techniques of brain training and compassion; the other was not. Compared to the non intervention group, students in the CBCT group reported increased compassion, and decreased loneliness and depression. Just like going to the gym builds physical muscles, strategies to help mindset can build resilience. Some of the known and researched strategies to help our health and mindset are: 1. Connection to others- family, friends, (and pets too!) 2. Nature- sunlight can increase the release of serotonin, a mood elevating hormone 3. Compassion and kindness to others- this actually activates the 'givers high' - and biologically, serotonin, dopamine levels often go up which reduces feelings of depression. As we head into the weekend, I hope we all have a chance to 'activate' our mindset, increase resilience and give our health a boost, by incorporating these 3 strategies. Have a great Saturday! Joan-Marie Stiglich, ELS Matthew Holland Jonathan Fisher, MD FACC Dr. Sharon Horesh Bergquist Vineet Arora MD MAPP Shikha Jain, MD, FACP Christian Bagge Meg Barron Brandon S. Aylward, PhD Solome Tibebu Navin Goyal MD Jennifer Shannon M.D. Rain Henderson Laxmi Naik MD, ABIHM, IFMCP, ABEM, ABOM Amy Wigler Prriti Narain Deepa Sheth Sachin H. Jain, MD, MBA #resilience #leadership #mentalwellness #balance #depression

When we talk about productivity, we often focus on time management. ⏰ And yes, how we manage our time is important. But I believe that how you manage your energy is even more important and can have a deeper impact when it comes to sustaining peak performance. It's not just about doing the right things, but also doing them at the right time, with the right energy. ⚡️ So what does that mean practically speaking? Here are some tips: 📆 Schedule Your Energy, Not Just Your Time: ○ Identify your energy peaks: Are you an early bird or a night owl? Schedule demanding tasks for your peak times and less demanding ones for when your energy dips. ○ Embrace the power of breaks: Don't push through exhaustion. Short, regular breaks can boost focus and prevent burnout. Try the Pomodoro Technique (25 minutes work, 5 minutes break) or find a rhythm that works for you. ○ Listen to your body: Pay attention to physical and mental cues of fatigue. Don't be afraid to take a walk, stretch, or meditate to recharge before diving back in. 💪 Fuel Your Body and Mind for Optimal Energy: ○ Eat for energy, not just for taste: Stock up on nutritious, whole foods that provide sustained energy. Limit processed foods, sugar, and excessive caffeine, which can lead to crashes. ○ Stay hydrated: Dehydration can zap your energy and focus. Aim for 8 glasses of water daily and adjust based on your activity level and climate. ○ Move your body: Exercise is a natural energy booster. Even a short walk or workout can improve focus, mood, and overall well-being. 💆♀️ Prioritize Rest and Recovery: ○ Get enough sleep: Aim for 7-8 hours of quality sleep each night. Optimize your sleep hygiene with a consistent bedtime routine and a dark, quiet sleeping environment. ○ Learn to say no: Don't overload your schedule. Prioritize tasks and delegate or decline those that drain your energy unnecessarily. ○ Schedule time for relaxation: Make time for activities you enjoy, whether it's reading, spending time in nature, or connecting with loved ones. These activities can help reduce stress and replenish your energy reserves. Remember, managing your energy is a journey, not a destination. Experiment with these tips and find what works best for you. Bonus Tip: Share your own energy management strategies in the comments! Let's build a community of support and learn from each other. #Productivity #EnergyManagement #PeakPerformance #WellBeing