New with Sierra there is a built-in utility to help keep disk storage space available. The function is part of the System Information.app and is accessed a few ways:
- => About This Mac => Storage => Manage…
- (Hold the option key down) => System Information… => Window => Storage Mangement (Cmd-U)
- /Applications/Utilities/System Information.app => Window => Storage Mangement (Cmd-U)
Once launched it will proceed to gather data sizes of categories of interest. The available and total disk space will be listed in the window’s name.

First you’ll see some recommendations of ways to keep disk space available. Each has its own set of gotchas so be sure to make note of the implications:
Store in iCloud —

There has been some interesting discoveries in the behavior surrounding iCloud Desktop and Documents. See iCloud Desktop and Documents in macOS Sierra – The Good, The Bad and the Ugly for a full rundown. Even though these checkboxes are checked by default, that doesn’t represent the actual state of the setting. On my machine I have Desktop and Documents turned off in the iCloud preference pane yet this box shows as checked.
Optimize Storage —

Empty Trash Automatically —

If you’re one of those that can’t commit to deleting things once put in the Trash, let the OS handle it for you.
Reduce Clutter —
This option opens the Documents listing.
Along the left are categories and the amount of space each is taking up. Accessing those brings up a list sorted by largest on top. If you want to remove an individual listing, right click and select Delete. Even though Applications are listed, non-admins can’t remove applications without admin credentials.
Thanks to @adamcodega for pointing this tool out.