Neuro-Oncology Advances Editor

The glioblastoma GBMdrug1000 dataset resource provides directions for future small molecule drug discovery

Time matters: The prognostic impact of diagnostic delay on survival in primary central nervous system lymphoma—a single-center, retrospective real-world study

The impact of postoperative ischemic changes on survival outcomes in IDH-wildtype glioblastoma

A case of radiation treatment effect mimicking viable, recurrent meningioma on DOTATATE PET imaging

Fusion transcriptome landscape in glioblastoma: Incidence and therapeutic implications

Desmoplastic infantile ganglioglioma/astrocytoma: Expanding the molecular and morphological spectrum with a novel BRAF fusion

Impact of extent of surgical resection on survival in World Health Organization grade 4 gliomas: A molecular subtype-based analysis

Improved target volume delineation for stereotactic radiosurgery in brain metastases using post-contrast 3D T1 TSE black-blood MRI

Limited evidence of pseudoprogression following immune checkpoint inhibitor (ICI) therapy in glioblastoma

Age-dependent glioma progression and functional decline in a syngeneic murine model

Impact of proton vs. photon radiotherapy on overall survival in the management of spinal chondrosarcoma and mortality risk prediction: A nationwide analysis

Preclinical assessment of checkpoint blockade combined with DNA methyltransferase inhibition in high-risk pediatric brain tumors reveals limited therapeutic synergy

Patient-derived organoids and neurospheres recapitulate salient features of primary tumor heterogeneity

2026 Issue

Apparent diffusion coefficient for genetic characterization of untreated adult gliomas: A meta-analysis stratified by methods

New biomarkers for the diagnosis of primary central nervous system lymphoma in CSF: A multicenter retrospective cohort study

New biomarkers for the diagnosis of primary central nervous system lymphoma in CSF: A multicenter retrospective cohort study

New biomarkers for the diagnosis of primary central nervous system lymphoma in CSF: A multicenter retrospective cohort study

Contrast clearance analysis in neuro-oncology: A systematic review and meta-analysis on differentiating posttreatment changes from tumor progression

Chimeric antigen receptor (CAR)-T-cell therapy for glioblastoma: what can we learn from the early clinical trials? A systematic review

Mapping glioma’s impact on cognition: Insights from macrostructure, microstructure, and beyond

New Issue: Neuro-Oncology Advances | Oxford Academic

Risk analysis of radiosurgery for vestibular schwannoma: Systematic review and comparative study of 10-year outcomes

Patient-derived Organoids and Neurospheres recapitulate salient features of primary tumor heterogeneity

Post-intrathecal chemotherapy-related paraplegia syndrome in hematological cancer patients: A systematic review

Neuroimaging of postoperative pediatric cerebellar mutism syndrome: a systematic review

A randomized controlled trial of a telehealth group cognitive intervention (LaTCH-BRAINS) to improve cognition after primary brain tumor diagnosis

Impact of the COVID-19 pandemic on primary brain tumor incidence and management: Decisions that went right

Revisiting pediatric HGGs and PNETs according to the WHO CNS5 criteria: A clinical and genomic retrospective analysis

Why publish

Glutamate to GABA ratio is elevated in patients with IDH-mutant lower-grade gliomas and seizures

Is tumor shape associated with molecular diagnosis, extent of resection, or postoperative focal deficits in diffuse low-grade gliomas?

The relationship between radiotherapy dose and cognitive outcomes in functional brain network hubs of glioma patients with predominantly left frontal lobe lesions

Abstracts from SNOSSA 2025: Innovation in Neuro-Oncology Care in Sub-Saharan Africa

First-in-human study of an EGFRvIII x CD3 T cell bispecific antibody in the treatment of newly diagnosed glioblastoma

Estimating overall survival of glioblastoma patients using clinical variables, tumor size, and location

Prediction of treatment failure and early identification of tumor progression after Gamma-Knife radiosurgery in vestibular schwannoma: A retrospective cohort study

Challenges in diagnostics and treatment of infant-type hemispheric gliomas

Neuro-Oncology Advaces

Bevacizumab alternating chemotherapy for improving the survival of patients with recurrent high-grade glioma

Building pediatric neuro-oncology capacity in LMICs through multidisciplinary education and collaboration: a mixed-methods analysis

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Prediction of early distant brain failure after stereotactic radiotherapy for brain metastases

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Blood-brain barrier disruption following MR-guided laser interstitial thermal therapy

Deep learning volumetrics reveal distinct clinical trajectories for pediatric low-grade gliomas under surveillance: A multicenter study

Radiomics based on MRI and 18F-FDG PET/CT predicts response to EGFR-TKI therapy based on primary NSCLC and brain metastasis

Phase II trial of nilotinib in PDGFR-alpha-enriched recurrent high-grade gliomas

Patterns of relapse in diffuse intrinsic pontine glioma after convection-enhanced delivery of 124I-omburtamab

Selumetinib in pediatric patients with neurofibromatosis type 1 and plexiform neurofibroma: Propensity score analysis of SPRINT vs. natural history control arm

Phase I study of NT-I7, a long-acting interleukin-7, in severe treatment-related lymphopenia following standard radiation and temozolomide for high-grade glioma

Translational advancements in tumor vaccine therapies for glioblastomas

Cellular immunotherapies for central nervous system cancers

Immunologic specificity in glioblastoma: Antigen discovery and translational implications

The glioma microenvironment and its impact on antitumor immunity

Within and beyond the tumor: Mechanisms of glioblastoma-induced immunosuppression

Why publish

Outcomes of pediatric medulloblastoma in low- and middle-income countries: A retrospective analysis of 335 cases from 8 countries

New Issue: CNO 2025 Meeting Abstracts

Health-related quality of life and psychological distress in patients with brain tumors and their families: A cross-sectional web survey

Long-term family outcomes in grade 2 IDH-mutated glioma patients treated with awake-guided surgery: Biological, professional, and therapeutic interactions

Risk factors, predictive models, and general work ability trajectory in patients with glioma

Advancing vaccine-based immunotherapy in glioblastoma treatment

Stereotactic radiosurgery and fractionated radiation therapy in the management of pituitary tumors

Mimickers of pituitary tumors

Nuances in visual rehabilitation after pituitary surgery

Beyond the sella: Expanded endoscopic endonasal approaches for pituitary tumors

Pituitary Tumors Supplement

Volume 7 Issue Supplement_1 | Neuro-Oncology Advances | Oxford Academic

Remembering Dr. Fred Gentili

Arterial spin labeling perfusion MRI differentiates between radiation necrosis and tumor in brain metastases treated with stereotactic radiosurgery

Open access

Identifying targetable alterations predictive of distant progression in glioblastoma patients undergoing standard therapy

PNOC009: Convection-enhanced delivery of liposomal irinotecan in patients with newly diagnosed diffuse intrinsic pontine glioma

Refinement of primary central nervous system lymphoma prognostication and response assessment using 3-dimensional MRI

New Articles

Molecular alterations in IDH-mutant astrocytoma: A multi-institutional retrospective study

Second-line temozolomide in first recurrent MGMT-methylated glioblastoma after lomustine/temozolomide: Efficacy and safety

High-grade, metastatic disease, and adjuvant radiotherapy are independent prognostic factors for progression-free survival in patients with solitary fibrous tumors

Primary central nervous system lymphoma: Predictors of response to induction therapy and patterns of progression

Metrics

Evaluating short-term survivors of glioblastoma: A proposal based on SEER registry data

Impact of resection location on depressive symptoms following glioma surgery

Multidisciplinary adolescent and young adult neuro-oncology clinic: Clinical cases, practice challenges, and future perspectives

Integrated early palliative care for patients with newly diagnosed glioblastoma: The GLIOSUPPORT feasibility study

Neuro-Oncology Pediatrics | Oxford Academic

Personalized targeted glioblastoma therapies by ex vivo drug screening: Study protocol of the Advanced brain Tumor TheRApy Clinical Trial (ATTRACT)

Blood group O attributes to prolonged progression-free survival, overall survival, and 5-year survival in isocitrate dehydrogenase-wildtype glioblastoma patients with MGMT promoter methylation

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Top read articles - May

Adverse neurologic events of immune checkpoint inhibitor monotherapy vs. combination therapy for melanoma

Establishment and validation of a nomogram for predicting IDH-wildtype glioblastomas in nonenhancing adult-type diffuse gliomas

Characterizing long- and short-survival glioblastoma patients with FLT-PET/MRI and metabolomics

Effect of bevacizumab on refractory meningiomas: 3D volumetric growth rate versus response assessment in neuro-oncology criteria

Sex-specific difference in treatment success/failure after vestibular schwannoma treatment

New-onset facial spasm is associated with treatment failure after radiosurgery in vestibular schwannoma

Outcomes in patients with multiple sclerosis and solid organ cancers treated with immune checkpoint inhibitors

Assessing the dose of regadenoson required to transiently alter blood-brain barrier integrity in patients with infiltrating gliomas

Current trends in the allocation of National Institute of Health funding of brain tumor research

Why publish in NOA

Phase 1 trial of hypofractionated stereotactic re-irradiation in combination with nivolumab, ipilimumab, and bevacizumab for recurrent high-grade gliomas

Functional connectivity between tumor region and resting-state networks as imaging biomarker for overall survival in recurrent gliomas diagnosed by O-(2-[18F]fluoroethyl)-l-tyrosine PET

Distant brain failure after stereotactic radiosurgery for brain metastases in patients receiving novel systemic treatments

Size matters: Early progression of melanoma brain metastases after treatment with immune checkpoint inhibitors

Carboplatin and vinblastine monthly in the optic pathway and hypothalamic gliomas: A retrospective analysis in a single institute

Rise in post-resection neutrophil-to-lymphocyte ratio correlates with decreased survival in glioblastoma patients

Fractionated reirradiation of recurrent high-grade gliomas: Safety with higher reirradiation dose and larger targets

Emerging mechanism and therapeutic potential of neurofibromatosis type 1-related nerve system tumor: Advancing insights into tumor development

A multi-institutional retrospective cohort of adult-onset medulloblastoma in the modern era

Real-world analysis of treatment patterns and survival outcome of glioblastoma patients in a German single-center study: Can survival rates of randomized controlled trials be achieved?

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Therapeutic manipulation and bypass of the blood–brain barrier: powerful tools in glioma treatment

Presentation, management, and outcomes of central nervous system metastases in Africa: Systematic review and meta-analysis

A single-arm phase 2 study of abemaciclib in adult patients with recurrent grade 3 oligodendroglioma

High-dose MTX-based polychemotherapy for primary CNS lymphoma in younger patients: Long-term efficacy of the modified Bonn protocol

Ivosidenib for the treatment of IDH1-mutant glioma, grades 2–4: Tolerability, predictors of response, and outcomes

The value of AI for assessing longitudinal brain metastases treatment response

2025 Edition

The Slovenian translational platform GlioBank for brain tumor research: Identification of molecular signatures of glioblastoma progression

Clinical value of the MGMT promoter methylation score in IDHmt low-grade glioma for predicting benefit from temozolomide treatment

Transcriptomic analysis of EGFR co-expression and activation in glioblastoma reveals associations with its ligands

Lack of ST2 aggravates glioma invasiveness, vascular abnormality, and immune suppression

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Sonic hedgehog medulloblastoma cells in co-culture with cerebellar organoids converge towards in vivo malignant cell states

Immunocompetent murine glioblastoma stem-like cell models exhibiting distinct phenotypes

Pediatric spinal high-grade glioma in the pediatric precision oncology registry INFORM: Identification of potential therapeutic targets

cIMPACT-NOW update 9: Recommendations on utilization of genome-wide DNA methylation profiling for central nervous system tumor diagnostics

Multi-center real-world data-driven web calculator for predicting outcomes in IDH-mutant gliomas: Integrating molecular subtypes and treatment modalities

AI-guided virtual biopsy: Automated differentiation of cerebral gliomas from other benign and malignant MRI findings using deep learning

Enhancing clinical decision-making: An externally validated machine learning model for predicting isocitrate dehydrogenase mutation in gliomas using radiomics from presurgical magnetic resonance imaging

Magnetic resonance imaging and o-(2-[18F]fluoroethyl)-l-tyrosine positron emission tomography for early response assessment of nivolumab and bevacizumab in patients with recurrent high-grade astrocytic glioma

Impact of tumor-treating fields on the survival of Japanese patients with newly diagnosed glioblastoma: A multicenter, retrospective cohort study

Watch-and-wait approach versus adjuvant treatment after radical awake resection in selected adult-type grade 3 gliomas, isocitrate dehydrogenase mutant: A case-matched cohort

Pediatric brain tumor classification using deep learning on MR images with age fusion

A single-center case study series assessing the effect of selumetinib use in patients with neurofibromatosis-related plexiform neurofibromas

2025 Issue

New articles

Non-small cell lung cancer with synchronous brain metastases: Identification of prognostic factors in a retrospective multicenter study (HOT 1701)

Analysis of safety and efficacy of proton radiotherapy for optic nerve sheath meningioma

Early experience and perioperative risk of GammaTile for upfront brain metastases: Report from a prospective multicenter study

Open access

A phase II, open-label, single-arm trial of pembrolizumab for recurrent meningioma and solitary fibrous tumor

Neuroanatomical profiles of cognitive phenotypes in patients with primary brain tumors

Level I and II deficits—A clinical survey on international practice of awake craniotomy and definitions of postoperative “major” and “minor” deficits

In situ optical feedback in brain tumor biopsy: A multiparametric analysis

Abstracts to the 42nd Annual Meeting of the Japan Society for Neuro-Oncology

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Ion channel modulator DPI-201-106 significantly enhances antitumor activity of DNA damage response inhibitors in glioblastoma

Latest Articles

miR-644a is a tumor cell-intrinsic mediator of sex bias in glioblastoma

Treatment-related survival patterns in diffuse intrinsic pontine glioma using a historical cohort: A report from the European Society for Pediatric Oncology DIPG/DMG Registry

Biological and prognostic relevance of epigenetic regulatory genes in high-grade gliomas

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Frequent Alzheimer’s disease neuropathological change in patients with glioblastoma

Glioma oncogenesis in the Constitutional mismatch repair deficiency (CMMRD) syndrome

Comprehensive multimodal deep learning survival prediction enabled by a transformer architecture: A multicenter study in glioblastoma

Directionally non-rotating electric field therapy delivered through implanted electrodes as a glioblastoma treatment platform: A proof-of-principle study

Predicting prognosis outcomes of primary central nervous system lymphoma with high-dose methotrexate-based chemotherapeutic treatment using lipidomics

Volume 6 Issue 1 | Neuro-Oncology Advances | Oxford Academic

A fast protocol for multicenter and multiparametric quantitative MRI studies in brain tumor patients using vendor sequences

Cytotoxicity on low-grade canine meningioma with the use of somatostatin analog (octreotide): An in vitro study

Advancing noninvasive glioma classification with diffusion radiomics: Exploring the impact of signal intensity normalization

Neuroanatomical profiles of cognitive phenotypes in patients with primary brain tumors

Cerebrospinal fluid liquid biopsy by low-pass whole genome sequencing for clinical disease monitoring in pediatric embryonal tumors

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Nonclinical pharmacodynamics of boron neutron capture therapy using direct intratumoral administration of a folate receptor targeting novel boron carrier

Prediction of WHO grade and methylation class of aggressive meningiomas: Extraction of diagnostic information from infrared spectroscopic data

Racial distribution of molecularly classified brain tumors

Diffuse low-grade glioma: What is the optimal linear measure to assess tumor growth?

Glioma-related epilepsy following low-grade glioma surgery

Analysis of the discontinuation and nonpublication of neurooncological randomized clinical trials

Phase 1 study of concomitant tumor treating fields and temozolomide chemoradiation for newly diagnosed glioblastoma

Exploring molecular glioblastoma: Insights from advanced imaging for a nuanced understanding of the molecularly defined malignant biology

Impact of intensity-modulated proton therapy in reducing radiation-induced lymphopenia in glioma patients

Diffuse glioma molecular profiling with arterial spin labeling and dynamic susceptibility contrast perfusion MRI: A comparative study

Unraveling glioblastoma diversity: Insights into methylation subtypes and spatial relationships

Differential gene expression underlying epileptogenicity in patients with gliomas

Clinical utility of DNA methylation profiling for choroid plexus tumors

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Medulloblastomas with ELP1 pathogenic variants: A weakly penetrant syndrome with a restricted spectrum in a limited age window

Imaging meningioma biology: Machine learning predicts integrated risk score in WHO grade 2/3 meningioma

Comparative evaluation of the diagnostic and prognostic performance of CNSide™ versus standard cytology for leptomeningeal disease

Most Read Articles

Longitudinal assessment of quality of life, neurocognition, and psychopathology in patients with low-grade glioma on first-line temozolomide: A feasibility study

Fibroblast growth factor receptor 1 gene mutation as a potential risk factor for spontaneous intracranial hemorrhage in pediatric low-grade glioma patients

Is Gamma Knife surgery, omitting adjunct whole brain radiation treatment, feasible for patients with 20 or more brain metastases?

Effective re-induction regimen for children with recurrent medulloblastoma

Clinical experiences and learning curves from robot-assisted neurosurgical biopsies with Stealth Autoguide™

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Pulsed reduced-dose rate re-irradiation for patients with recurrent grade 2 gliomas

POLARIS: A phase 2 trial of encorafenib plus binimetinib evaluating high-dose and standard-dose regimens in patients with BRAF V600-mutant melanoma with brain metastasis

Effect of food on selumetinib pharmacokinetics and gastrointestinal tolerability in adolescents with neurofibromatosis type 1-related plexiform neurofibromas

[11C]-methionine positron emission tomography in the evaluation of pediatric low-grade gliomas

Unique genomic alterations in the circulating tumor DNA of patients with solid tumors brain metastases

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Hippocampal subfield volumetric changes after radiotherapy for brain metastases

Antiangiogenic exclusion rules in glioma trials: Historical perspectives and guidance for future trial design

Latest Articles

Unraveling the relations between post-traumatic stress symptoms, neurocognitive functioning, and limbic white matter in pediatric brain tumor patients

Tumor location and neurocognitive function—Unravelling the association and identifying relevant anatomical substrates in intra-axial brain tumors

Artificial-intelligence-driven measurements of brain metastases’ response to SRS compare favorably with current manual standards of assessment

Long-term survivors of glioblastoma: Tumor molecular, clinical, and imaging findings

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A multi-institutional phase I study of acetazolamide with temozolomide in adults with newly diagnosed MGMT-methylated malignant glioma

Analysis of demographics and the impact of adjuvant radiotherapy on a nationwide cohort of patients with high-grade spinal meningiomas

Prediction of MGMT promotor methylation status in glioblastoma by contrast-enhanced T1-weighted intensity image

Unsupervised machine learning models reveal predictive clinical markers of glioblastoma patient survival using white blood cell counts prior to initiating chemoradiation

Adult neuro-oncology trials in the United States over 5 decades: Analysis of trials completion rate to guide the path forward

Molecular prognostication in grade 3 meningiomas and p16/MTAP immunohistochemistry for predicting CDKN2A/B status

Comparison of volumetric and 2D-based response methods in the PNOC-001 pediatric low-grade glioma clinical trial

Quantification of perineural satellitosis in pretreatment glioblastoma with structural MRI and a diffusion tensor imaging template

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Structural connectome-based predictive modeling of cognitive deficits in treated glioma patients

Neuro-Oncology Advances

Homeostatic iron regulatory protein drives glioblastoma growth via tumor cell-intrinsic and sex-specific responses

Volumetric analysis: Rethinking brain metastases response assessment

Comparison meta-analysis of intraoperative MRI-guided needle biopsy versus conventional stereotactic needle biopsies

Highly cited research

The prevalence and severity of fatigue in meningioma patients and its association with patient-, tumor- and treatment-related factors

Treatment of unmethylated MGMT-promoter recurrent glioblastoma with cancer stem cell assay-guided chemotherapy and the impact on patients’ healthcare costs

Diffusion basis spectrum imaging as an adjunct to conventional MRI leads to earlier diagnosis of high-grade glioma tumor progression versus treatment effect

Abstracts to the 41st Annual Meeting of the Japan Society for Neuro-Oncology

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An expanded role for surgery in grade 3 1p/19q co-deleted oligodendroglioma

Prospective phase II trial of the dual mTORC1/2 inhibitor vistusertib for progressive or symptomatic meningiomas in persons with neurofibromatosis 2

Neuro-Oncology Advances

Feasibility of deep learning-based tumor segmentation for target delineation and response assessment in grade-4 glioma using multi-parametric MRI

Characterization of recurrence patterns and outcomes of medulloblastoma in adults: The University of Texas MD Anderson Cancer Center experience

Efficacy of laser interstitial thermal therapy for biopsy-proven radiation necrosis in radiographically recurrent brain metastases

MR elastography identifies regions of extracellular matrix reorganization associated with shorter survival in glioblastoma patients

Assessing the added value of apparent diffusion coefficient, cerebral blood volume, and radiomic magnetic resonance features for differentiation of pseudoprogression versus true tumor progression in patients with glioblastoma

Abstracts from the 2023 Annual Meeting of the Society for Neuro-Oncology Sub-Saharan Africa

Epidemiological trends, prognostic factors, and survival outcomes of synchronous brain metastases from 2015 to 2019: a population-based study

Phase II study of everolimus for recurrent or progressive pediatric ependymoma

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Integrated response analysis of pediatric low-grade gliomas during and after targeted therapy treatment

Metrics and Tracking at NOA

Cerebrospinal fluid metabolic markers predict prognosis behavior of primary central nervous system lymphoma with high-dose methotrexate-based chemotherapeutic treatment

Liquid biopsy with multiplex ligation-dependent probe amplification targeting cell-free tumor DNA in cerebrospinal fluid from patients with adult diffuse glioma

Collagen deposition within brain metastases is associated with leptomeningeal failure after cavity-directed radiosurgery

Tumor microenvironment in glioblastoma: Current and emerging concepts

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NS-HGlio: A generalizable and repeatable HGG segmentation and volumetric measurement AI algorithm for the longitudinal MRI assessment to inform RANO in trials and clinics

New Supplement - Neuro-Oncology Advances

Investigation of neurophysiologic and functional connectivity changes following glioma resection using magnetoencephalography

Clinical utility of whole-genome DNA methylation profiling as a primary molecular diagnostic assay for central nervous system tumors—A prospective study and guidelines for clinical testing

Low-pass whole-genome and targeted sequencing of cell-free DNA from cerebrospinal fluid in pediatric patients with central nervous system tumors

Screening of predicted synergistic multi-target therapies in glioblastoma identifies new treatment strategies

New Articles

Predicting methylation class from diffusely infiltrating adult gliomas using multimodality MRI data

WSD-0922, a novel brain-penetrant inhibitor of epidermal growth factor receptor, promotes survival in glioblastoma mouse models

Deep proteome investigation of high-grade gliomas reveals heterogeneity driving differential metabolism of 5-aminolevulinic acid

Glioblastoma extracellular vesicles influence glial cell hyaluronic acid deposition to promote invasiveness

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