CUREDAO

I KNOW THIS

SOUNDS

CRAZY.

What if humanity took 1% of the money we spend on our capacity for apocalypse and instead spent it on curing diseases?

THE QUESTION

Adjust the slider to show how you'd split your country's finite resources between the military (weapons and armed forces) and clinical trials to cure and treat disease.

50%
Military & Weapons
50%
Clinical Trials

2 BILLION PEOPLE ARE

SUFFERING

FROM CURABLE DISEASES

FOR 2 REASONS:

REASON 1.

The Current System of Clinical Research Is Slow and Terrible

💰

82xX Higher Costs Than Necessary

Everything costs 82x times more than it should. Efficiency is for other industries.

👥

$41K Cost Per Participant

It costs $41K to include one person in a study. That's more than most people make in a year.

💸

$2.6B Development Cost

To make one new drug costs $2.6B. Then they charge sick people to pay it back.

☠️

21K-120K Preventable Deaths

Between 21,000 and 120,000 people die every decade because the paperwork takes too long.

🚫

86.1% of Patients Excluded

86.1% of sick people can't join trials. Apparently they're not sick in the right way.

💊

95% of Diseases Untreated

95% of diseases have no cure. We're really good at the other 5%, though.

🤒

17 Years of Suffering

It takes 17 years from 'we found a cure!' to actually getting it. Most of us will be dead by then.

⚛️

45.1B Untested Treatments

45.1B possible cures exist. We've tested approximately none of them.

🌍

2.4B People Suffering

2.4B people are sick right now. The system is working exactly as designed.

🧫

44+ Years Since Last Disease Cure

We haven't cured a major disease in 44 years. But don't worry, we're very busy.

REASON 2.

HUMANITY SPENDS

40X MORE ON WAR

THAN CURING ALL DISEASES COMBINED

MILITARY
$2.7T
$2.7T FOR
THE WAR ON HUMANITY
MEDICAL RESEARCH
$67.5B
$67.5B FOR
THE WAR ON DISEASE

WE CAN SOLVE BOTH OF THESE PROBLEMS SIMULTANEOUSLY

OXFORD RECOVERY TRIAL PROVED RESEARCH CAN BE DONE FOR

$500
PER PATIENT IN PRAGMATIC TRIALS
VS
$41K
PER PATIENT IN STANDARD TRIALS

Why The Bottleneck Is Clinical Trials, Not Basic Science

The Vast Unexplored Therapeutic Frontier

10K
Known Safe Compounds
FDA-approved drugs + GRAS substances already proven safe in humans
9.5M
Possible Combinations
9500 compounds × ~1,000 diseases
33K
Actually Tested
Approved uses + repurposed + failed trials
99.7%
OF DRUG-DISEASE COMBINATIONS NEVER TESTED
Only 0.34% of the therapeutic frontier has been explored. The treatments may already exist among known-safe compounds - we just haven't tested them.
Exploration Ratio=33K tested9.5M possible=0.34%\text{Exploration Ratio} = \frac{\text{33K tested}}{\text{9.5M possible}} = 0.34\%
Therapeutic Frontier Explored
TESTED (0.34%)
UNEXPLORED (99.7%)

That tiny line on the left? That's ALL of modern medicine.

You cannot have "diminishing returns" when you haven't even started.

Wait, it gets worse: The FULL therapeutic frontier

The 9.5M figure above only counts single drugs against diseases. Modern medicine increasingly uses combination therapies (standard in oncology, HIV, cardiology).

9.5M
Single Drugs × Diseases
What we showed above
45.1B
Drug Pairs × Diseases
Combination therapy space
42.0M
Emerging Modalities
Gene therapy, mRNA, cell therapy
45.1B
Total Therapeutic Frontier
That's 45.1B combinations we could test. We've tested about 33K. Do the math on "diminishing returns."

Note: We use the conservative 9.5M figure in our main calculations because single-drug trials are more straightforward. But the combination therapy space shows the true scale of unexplored medicine.

Years to Universal Treatment Coverage

The Core Problem
6,650
Diseases Without Effective Treatment
~15
First Treatments Discovered Per Year
At current clinical trial capacity
443
Years to Cover All Diseases
6,650 ÷ 15/yr
Status Quo

Clinical trials are how we discover which treatments work for which diseases. At current trial capacity, we find first effective treatments for only ~15 diseases per year.

443 Years
To find treatments for all 6,650 diseases
That's longer than recorded human history
222 Years
Average wait for any single disease
If you have an untreated disease, you'll likely wait ~222 years for a first effective treatment
With 12× Trial Capacity

Pragmatic trials cost ~44× less than traditional trials. The treaty would fund 12× more trials = ~180 first treatments per year.

36 Years
To cover all 6,650 diseases
443 years ÷ 12× capacity = 36 years
Addressing the "Diminishing Returns" Argument

Critics argue: "Just funding more trials won't proportionally increase discoveries - we've picked the low-hanging fruit."

This is wrong for six reasons:

1.
We haven't picked the fruit at all.
99.7% of drug-disease combinations are unexplored. You can't have diminishing returns when you haven't started.
2.
The bottleneck is trials, not candidates.
10K safe compounds sit untested. The limiting factor isn't discovering molecules - it's the capacity to test them.
3.
40% of promising drugs die from COST, not science.
The "Valley of Death" kills 40% of promising candidates not because they don't work, but because testing is too expensive. That's not diminishing returns - that's artificial scarcity.
4.
When we DO test old drugs, 30% find new uses.
Drug repurposing has a 30% success rate - triple the 10% rate of new drug development. The low-hanging fruit is literally everywhere.
5.
The treatment gap is real and growing.
6,650 diseases have no treatment. At ~15 first treatments/year, we'll never catch up. With 12× more trials, we actually have a shot.
6.
More trials = compounding returns, not diminishing.
Every trial teaches us more about biology. More data → better target selection → higher success rates. AI/ML models trained on trial data improve predictions. The more we test, the better we get at testing.

Diminishing returns apply to repeated attempts at the same problem. We're proposing to attempt problems we've never tried.

Two Possible Futures

Years of Suffering
0M
Year 0dFDA (37y)Year 443
Adjust Funding
See how more funding shrinks the timeline
1×5×10×
$27.2B/year
Treaty baseline
= 12× trial capacity = 37 years
Make It Personal
Enter your age to see YOUR milestones
years old
You Are Here
Year 0 - Decision Point
52B
104B
156B
208B
260B
312B
364B
416B
dFDA Complete
37 years
Still 406 years to go...
All Diseases Covered
443 years

The treatments exist. The safe compounds exist. The patients are waiting.

The only missing ingredient is trial capacity. That's a logistics problem, not a scientific frontier.

See the ROI →
THE 1% TREATY
Would REDIRECT
1% OF GLOBAL MILITARY SPENDING
TO RADICALLY ACCELERATE MEDICAL PROGRESS BY ALLOWING ANY PATIENT TO PARTICIPATE IN PRAGMATIC TRIALS
MILITARY
$2.693T
1% REDUCTION 👉
MEDICAL RESEARCH
$94.7B
$67.5B CURRENT
👈+$27.2B INCREASE FROM 1% TREATY
DON'T WORRY.
with the remaining $2.693T, WE'D STILL HAVE ENOUGH BULLETS, MISSILES, AND NUCLEAR BOMBS TO KILL EVERY MAN, WOMAN, AND CHILD ON EARTH 19 TIMES
(which should be more than sufficient)

WHAT $27.2B COULD BUY

41K+
HYPER-EFFICIENT PRAGMATIC TRIALS
INTEGRATED INTO STANDARD HEALTHCARE
23M+
PATIENTS TREATED
WITH THE MOST PROMISING NEW THERAPIES
TREATMENTS
FOR EVERY DISEASE
95% OF DISEASES HAVE ZERO FDA-APPROVED TREATMENTS
1%
FEWER BOMBS
POINTED AT EVERYONE

A DECENTRALIZED FRAMEWORK FOR DRUG ASSESSMENT

CONSUMER REPORTS FOR DRUGS

A decentralized framework for drug assessment integrated into standard healthcare could both radically improve safety and allow patients to effortlessly participate in pragmatic decentralized clinical trials.

Search Any Treatment

Find drugs, supplements, diets, devices - everything ranked by real-world effectiveness

See Real Outcomes

Not marketing claims. Actual data from millions of real patients showing what works

Join Trials Instantly

One-click enrollment in pragmatic trials. Get paid to test treatments while helping humanity

Consumer Reports for Drugs

Transparent rankings based on effectiveness, side effects, and cost-effectiveness

HOW IT WORKS (FOR PATIENTS)

1

YOU SEARCH

Enter your condition. Get a ranked list of every treatment ever tested.

2

YOU COMPARE

See side-by-side outcomes: LDL reduction, survival rates, quality of life - actual numbers, not promises.

3

YOU DECIDE

Choose based on data, not marketing budgets. Your body, your choice, informed by millions of data points.

82X
CHEAPER
$500/patient (Oxford RECOVERY) vs $48K (traditional trials)
2 YEARS
NOT 17
Time to get life-saving treatments to patients who need them now
$50B
SAVED
Annual R&D cost savings from decentralized pragmatic trials

Outcome Labels

  • Comprehensive health impact data
  • Both positive and negative effects
  • Evidence-based decision making
Atorvastatin 20mg dailyLipid-lowering agent
Primary Outcomes
LDL Cholesterol(baseline: 160 mg/dL)
-43% (-69 mg/dL)
Total Cholesterol(baseline: 240 mg/dL)
-32% (-77 mg/dL)
Cardiovascular Event Risk(10-year risk)
-36% (-4.2%)
Secondary Benefits
HDL Cholesterol
+5% (+2.3 mg/dL)
Triglycerides
-22% (-35 mg/dL)
Side Effects
Muscle Pain/Weakness(vs. placebo)
+8.2% (NNH: 12)
Liver Enzyme Elevation
+1.2% (NNH: 83)
Headache
+3.8% (NNH: 26)

Source information not available.

NNH = Number Needed to Harm (patients treated for one additional adverse event)

TREATMENT RANKINGS

Interventions by Condition
Ranked by effectiveness based on clinical trials and real-world evidence
Loading conditions...

Treatment Data Coming Soon

We're currently generating evidence-based treatment rankings for Depression.

Our AI is analyzing clinical trials and meta-analyses. Check back soon!

💰 THE MATH

The Returns on Not Dying

When you stop making people fill out paperwork and start letting them not die, something magical happens:

637:1
RETURN ON INVESTMENT

$637 returned for every $1 invested

Not a typo. Not a fever dream. Actual math.

This beats humanity's previous greatest hits in the "not dying" genre:

1% Treaty → DIH + dFDA
637:1
Smallpox Eradication
280:1
Childhood Vaccinations
13:1

WHERE THE VALUE COMES FROM:

$58.6B
ANNUAL RESEARCH SAVINGS
Drug trials cost 82x less
86K
QALYS GAINED ANNUALLY
Quality-adjusted life years

Value comes from faster drug approvals (17 years → 2 years), better treatment matching through real-world data, and addressing neglected diseases that companies ignore.

♾️ The Math That Broke Excel

A 84.8M:1 Return on Investment

A $1.0B campaign yields $84.8 Quadrillion in health value.

ROI=Health Value CreatedCampaign Cost=$84.8Quadrillion$1.0B=84.8M:1\begin{aligned} \text{ROI} &= \frac{\text{Health Value Created}}{\text{Campaign Cost}} \\[1em] &= \frac{\$84.8 Quadrillion}{\$1.0B} = 84.8M:1 \end{aligned}

Where The Value Comes From:

$1.0B
Campaign Cost
Total investment needed
$84.8 Quadrillion
Health Value
From timeline acceleration
10.7B
Lives Saved
From treatments arriving earlier
$58.6B/yr
R&D Savings
Per year, forever

Math says this is the best possible use of a billion dollars.

Math is rarely wrong about money. People are frequently wrong about money.

SEE THE FULL MATH →

Charts, breakdowns, and all the nerdy details

THE QUESTION

Adjust the slider to show how you'd split your country's finite resources between the military (weapons and armed forces) and clinical trials to cure and treat disease.

50%
Military & Weapons
50%
Clinical Trials

YOUR VOTE'S IMPACT

38.4
LIVES SAVED PER VOTE

$27.2B/year scales trial capacity 12X, achieving 246 years of progress in 20

By eliminating the 8.2-year regulatory delay through pragmatic trials integrated into standard care

787
YEARS SUFFERING PREVENTED
$302.8M
ECONOMIC VALUE
30s
TO VOTE

Highest ROI Action in History

In 30 seconds, you can save more lives than most people save in a lifetime.

DO SOMETHING

OPTION 1: LEARN
DOWNLOAD THE MATH
43 studies. 82X proven. Peer-reviewed.
OPTION 2: ANSWER
THE MOST IMPORTANT QUESTION
30 seconds. Anonymous. Historical.
OPTION 3: FUND
DONATE (TAX-DEDUCTIBLE)
501(c)(3). Every dollar to creating a world without disease.
OPTION 4: DO NOTHING
DIE FROM SOMETHING PREVENTABLE
And watch everyone you've every loved slowly dissolve.

💀 DEATH CLOCK

0
PEOPLE DIED TODAY
0
PEOPLE DIED THIS YEAR
while we waste billions building nuclear bombs 💣☢️ and skynet 🤖

BOTTOM
LINE

SUFFERING: OPTIONAL
SOLUTION: PROVEN
COST: 1% OF MURDER BUDGET
ACTION: REQUIRED
TIME: NOW
MAKING SUFFERING OPTIONAL THROUGH MATH